Sudemycin E |CAS:1197054-49-1 Probechem Biochemicals

Chemical Structure : Sudemycin E

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Sudemycin E

货号: PC-62421Not For Human Use, Lab Use Only.

Sudemycin E is an alternative splicing inhibitor that binds to the U2 small nuclear ribonucleoprotein (snRNP) component SF3B1, causes a rapid change in alternative pre-messenger RNA splicing.

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生物&药学活性

Sudemycin E is an alternative splicing inhibitor that binds to the U2 small nuclear ribonucleoprotein (snRNP) component SF3B1, causes a rapid change in alternative pre-messenger RNA splicing.
Sudemycin E changes overall gene expression and arrest in the G2 phase of the cell cycle, and causes a loss of the H3K36me3 modification in chromatin encoding these exons.
Sudemycin E induces changes in chromatin modifications that result in chromatin condensation.

物理化学性质&存储条件

分子量	491.625
分子式	C27H41NO7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Isobutyric acid (2S,3Z)-5-[[cis-2-[(2E,4E)-5-[(3R,5S)-7,7-dimethyl-1,6-dioxaspiro[2.5]octan-5-yl]-3-methyl-2,4-pentadienyl]-1,3-dioxan-5-yl]amino]-5-oxopent-3-en-2-yl ester

参考文献

1. Convertini P, et al. Nucleic Acids Res. 2014 Apr;42(8):4947-61.

2. Thénoz M, et al. Retrovirology. 2014 Dec 18;11:119.

Sudemycin E

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Sudemycin E

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