Spiropiperidine 1 | M1 mAChR agonist | Probechem Biochemicals

Chemical Structure : Spiropiperidine 1

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Spiropiperidine 1 (SPP1)

货号: PC-35835Not For Human Use, Lab Use Only.

Spiropiperidine 1 (SPP1) is a potent, functionally selective and brain penetrant M1 orthosteric agonist with Ki of 21.3 nM for hM1 receptors.

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生物&药学活性

Spiropiperidine 1 (SPP1) is a potent, functionally selective and brain penetrant M1 orthosteric agonist with Ki of 21.3 nM for hM1 receptors.
Spiropiperidine 1 stimulates Gq mediated GTPγ[35S] signaling with IC50 of 12.3 nM, stimulates Gq mediated signaling in membranes prepared from rat cortex with EC50 of 21 nM。
Spiropiperidine 1 displays high functional selectivity for M1 receptors over native M2 and M3 receptor anti-targets and over a panel of other targets.

物理化学性质&存储条件

分子量	426.561
分子式	C24H34N4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	cyclopropyl 4-(3-methyl-4-oxo-1-(m-tolyl)-1,3,8-triazaspiro[4.5]decan-8-yl)piperidine-1-carboxylate

参考文献

1. Broad LM, et al. Br J Pharmacol. 2018 Oct 1. doi: 10.1111/bph.14510.

Spiropiperidine 1 (SPP1)

生物&药学活性

物理化学性质&存储条件

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Spiropiperidine 1 (SPP1)

生物&药学活性

物理化学性质&存储条件

参考文献

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