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首页-小分子抑制剂&激动剂-GPCR-Sigma Receptor-Sigma1-IN-4
Sigma1-IN-4

Chemical Structure : Sigma1-IN-4

CAS No.: 1541941-57-4

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Sigma1-IN-4

货号: PC-62827Not For Human Use, Lab Use Only.

Sigma1-IN-4 is a novel small molecule sigma-1 receptor inhibitor with Ki of 38 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    Sigma1-IN-4 is a novel small molecule sigma-1 receptor inhibitor with Ki of 38 nM.
    Sigma1-IN-4 has weak hERG inhibition (IC50>400 nM) and good in vitro ADME.
    Sigma1-IN-4 is a useful tool compound for use in future studies to validate sigma for in vivo efficacy in mouse models of CRPC.

    物理化学性质&存储条件

    分子量 321.78
    分子式 C16H17ClFN3O
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1-(4-chlorophenyl)-3-(3-(4-fluorophenoxy)propyl)guanidine

    参考文献

    1. Salvino JM, et al. Bioorg Med Chem Lett. 2017 May 15;27(10):2216-2220.

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