Selitrectinib (LOXO-195) | Trk inhibitor | Probechem Biochemicals

Chemical Structure : Selitrectinib

CAS No.: 2097002-61-2

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Selitrectinib (LOXO-195, LOXO195)

货号: PC-60901Not For Human Use, Lab Use Only.

LOXO-195 (Selitrectinib, LOXO195) is a potent, selective, next-generation Trk tyrosine kinase inhibitor with IC50 of 0.6 nM and <2.5 nM for WT TrkA and WT TrKC, respectively.

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5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥2180	In stock
50 mg	￥3680	In stock
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生物&药学活性

LOXO-195 (Selitrectinib, LOXO195) is a potent, selective, next-generation Trk tyrosine kinase inhibitor with IC50 of 0.6 nM and <2.5 nM for WT TrkA and WT TrKC, respectively.
LOXO-195 also diplays high potentcy against mutant TrkA G595R, TrkA G667C, TrkC G623R and TrkC G696A with IC50 of 2.0, 9.8, 2.3 and <2.5 nM, respectively.
LOXO-195 overcomes acquired resistance mediated by recurrent kinase domain (solvent front and xDFG) mutations identified in multiple patients.

物理化学性质&存储条件

分子量	380.427
分子式	C20H21FN6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(13E,14E,22R,6R)-35-fluoro-6-methyl-7-aza-1(5,3)-pyrazolo[1,5-a]pyrimidina-3(3,2)-pyridina-2(1,2)-pyrrolidinacyclooctaphan-8-one

参考文献

1. Drilon A, et al. Cancer Discov. 2017 Sep;7(9):963-972.

Selitrectinib (LOXO-195, LOXO195)

生物&药学活性

物理化学性质&存储条件

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Selitrectinib (LOXO-195, LOXO195)

生物&药学活性

物理化学性质&存储条件

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