SZU-B6

Chemical Structure : SZU-B6

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货号: PC-23239Not For Human Use, Lab Use Only.

SZU-B6 is a highly potent and selective SIRT6 PROTAC degrader with DC50 of 45.29 nM and 154.28 nM in SK-HEP-1 and Huh-7 cells respectively.

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生物&药学活性

SZU-B6 is a highly potent and selective SIRT6 PROTAC degrader with DC50 of 45.29 nM and 154.28 nM in SK-HEP-1 and Huh-7 cells respectively.
Coincubation with the proteasome inhibitor MG132 completely disabled the SIRT6 degradation effect of SZU-B6. SZU-B6 exhibited inhibitory effects on the viability of SK-HEP-1 cells with IC50 of 1.51 uM, induced cell cycle arrest and apoptosis.
SZU-B is mediated through the recruitment of CRBN E3 ligase for SIRT6 polyubiquitination and proteasome-dependent proteolysis.
SZU-B6 exhibited significant synergistic effect in suppressing tumor growth in HCC xenografts when combined with the kinase inhibitor sorafenib or irradiation.

物理化学性质&存储条件

分子量	593.62
分子式	C29H32FN7O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(4-((4-(3-Amino-4-nitrophenyl)piperazin-1-yl)methyl)piperidin-1-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione

参考文献

1. Huang J, et al. J Med Chem. 2024 Oct 10;67(19):17319-17349.

SZU-B6

生物&药学活性

物理化学性质&存储条件

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SZU-B6

生物&药学活性

物理化学性质&存储条件

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