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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Parasite-SW584
SW584

Chemical Structure : SW584

CAS No.:

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SW584 (SW 584, SW-584)

货号: PC-22800Not For Human Use, Lab Use Only.

SW584 is a potent, species-selective, orally active inhibitor of P. falciparum proteasome β5 active site (Pf20Sβ5) with IC50 of 5.8 nM, shows antimalarial activity with EC50 of 3 nM (Pf3D7 and PfDd2).

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

SW584 is a potent, species-selective, orally active inhibitor of P. falciparum proteasome β5 active site (Pf20Sβ5) with IC50 of 5.8 nM, shows antimalarial activity with EC50 of 3 nM (Pf3D7 and PfDd2).

物理化学性质&存储条件

分子量 420.50
分子式 C20H25FN4O3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-1-(2-(2-fluoroethoxy)acetyl)-N-((4-(6-methylpyridin-3-yl)thiazol-2-yl)methyl)piperidine-3-carboxamide

参考文献

1. Aloysus Lawong, et al. Cell Chem Biol, July 30, 2024

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