SUVN-G3031 (Samelisant) free base | H3R inverse agonist

Chemical Structure : SUVN-G3031 free base

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SUVN-G3031 free base (Samelisant free base)

货号: PC-35982Not For Human Use, Lab Use Only.

SUVN-G3031 (Samelisant) free base is a potent, selective, orally active histamine H3 receptor (H3R) inverse agonist with Ki of 8.73 nM (hH3R).

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生物&药学活性

SUVN-G3031 (Samelisant) free base is a potent, selective, orally active histamine H3 receptor (H3R) inverse agonist with Ki of 8.73 nM (hH3R).
SUVN-G3031 exhibited an IC50 of 20 nM with progressive inhibition of (R)-α-methylhistamine (0.03 µM) induced agonist activity in [35S]-GTPγS binding assay using CHO-K1 cells expressing human H3R membranes.
SUVN-G3031 reverses (R)-α-methylhistamine induced dipsogenia in vivo.

物理化学性质&存储条件

分子量	373.497
分子式	C21H31N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[4-(l-Cyclobutylpiperidin-4-yloxy) phenyl]-2-(morpholin-4-yl) acetamide

参考文献

1. Nirogi R, et al. J Med Chem. 2019 Jan 10. doi: 10.1021/acs.jmedchem.8b01280.

SUVN-G3031 free base (Samelisant free base)

生物&药学活性

物理化学性质&存储条件

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SUVN-G3031 free base (Samelisant free base)

生物&药学活性

物理化学性质&存储条件

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