STING inhibitor 42

Chemical Structure : STING inhibitor 42

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货号: PC-23966Not For Human Use, Lab Use Only.

STING inhibitor 42 is a potent, orally bioavailable STING inhibitor with IC50 of 34.2 nM and 7.1 nM for human and murine STING respectively.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

STING inhibitor 42 is a potent, orally bioavailable STING inhibitor with IC50 of 34.2 nM and 7.1 nM for human and murine STING respectively.
STING inhibitor 42 dose-dependently suppressed the induction of STING downstream genes (e.g., IFNB, ISG15, CXCL10, and IL6) expression in THP1 and L929 cells activated by 2′,3′-cGAMP.
STING inhibitor 42 could block the STING palmitoylation induced by 2′,3′-cGAMP in THP1 cells.
STING inhibitor 42 (10 mg/kg, oral) significantly suppressed STING-related inflammatory response in the CMA-treated model and Trex1–/– mouse model.

物理化学性质&存储条件

分子量	403.86
分子式	C21H20ClF2N3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(5-Chloro-1H-indol-3-yl)-3-(4-(4,4-difluorocyclohexyl)phenyl)urea

参考文献

1. Han X, et al. J Med Chem. 2025 Jan 28. doi: 10.1021/acs.jmedchem.4c02200.