欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-Immunology/Inflammation-STING-STING agonist BNBC
STING agonist BNBC

Chemical Structure : STING agonist BNBC

CAS No.: 55171-63-6

加入收藏

STING agonist BNBC (BNBC)

货号: PC-73024Not For Human Use, Lab Use Only.

STING agonist BNBC (BNBC) is a human STING specific agonist that activates cGAS-STING pathway in a functional human STING-dependent manner.

规格 价格 库存 数量
25 mg Get quote
50 mg Get quote
100 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    STING agonist BNBC (BNBC) is a human STING specific agonist that activates cGAS-STING pathway in a functional human STING-dependent manner.
    BNBC induced ISG54-driven luciferase expression in HepAD38/cGAS-STING/ISG54 cells, did not induce luciferase expression in HepAD38/cGAS-STINGΔC/ISG54Luc cells that express human STING with truncation of carboxyl-terminal domain (CTD).
    BNBC also concentration-dependently induced ISG54 driven luciferase expression in HepG2/STING/ISG54 reporter cells lacking cGAS.
    BNBC induced a proinflammatory cytokine response and establishment of antiviral state in human foreskin fibroblast cells (THF) in a STING-dependent manner.
    Pretreatment of THF cells with BNBC inhibited the replication of Dengue, Yellow fever, and Zika viruses. induced inflammatory cytokine response in human PBMCs and promoted PBMC-derived dendritic cell maturation.
    BNBC activated type I and III interferon dominated inflammatory cytokine response in PBMC-derived dendritic cells..
    BNBC induced the expression of interferon and other proinflammatory cytokines in HepG2 cells expressing functional human, but not mouse STING.

    物理化学性质&存储条件

    分子量 370.202
    分子式 C18H12BrNO3
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    6-bromo- N-(naphthalen-1-yl)benzo[ d][1,3]dioxole-5-carboxamide

    参考文献

    1. Zhang X, et al. ACS Infect Dis. 2019 May 14. doi: 10.1021/acsinfecdis.9b00010.

    备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

    联系我们 sales@probechem.com

    Bulk Inquiry

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • *Additional Information:

    询单

    • *产品名称:
    • *姓名:
    • *邮箱:
    • *公司名称:
    • *询单数量:
    • *国籍:
    • 询单信息: