STING agonist 22

Chemical Structure : STING agonist 22

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货号: PC-73356Not For Human Use, Lab Use Only.

STING agonist 22 is a novel, non-nucleotide specific small-molecule STING agonist with IC50 of 28, 11 uM for human STING isoforms WT and HAQ, respectively.

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生物&药学活性

STING agonist 22 is a novel, non-nucleotide specific small-molecule STING agonist with IC50 of 28, 11 uM for human STING isoforms WT and HAQ, respectively.
STING agonist 22 did not show any cytotoxicity in an immune cell proliferation panel across a variety of immune cell types and also did not show any activity in a kinome panel.
STING agonist 22 introduced higher levels of iFIT3 and MX1 mRNA across three different donors possessing different STING genotypes: WT/WT, WT/HAQ, and WT/R232H in human PBMCs (IC50=5-35 uM).
STING agonist 22 demonstrated in vivo antitumor effect in an MC38 mice model, with STING pathway activation and production of type I IFNs and proinflammatory cytokines, serum levels of IL-6, G-SCF, and MIP-1β.

物理化学性质&存储条件

分子量	384.776
分子式	C18H13ClN4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	methyl 3-chloro-5-methyl-2-((pyrazolo[1,5-a]pyrimidine-3-carboxamido)methyl)benzofuran-7-carboxylate

参考文献

1. Emily C Cherney, et al. J Med Chem. 2022 Feb 24;65(4):3518-3538.

STING agonist 22

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STING agonist 22

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