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首页-小分子抑制剂&激动剂-GPCR-Adrenergic Receptor-STD-101-D1
STD-101-D1

Chemical Structure : STD-101-D1

CAS No.: 2151041-09-5

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STD-101-D1

货号: PC-61776Not For Human Use, Lab Use Only.

STD-101-D1 is a novel brain permeable, G protein-biased beta-1 adrenergic receptor (ADRB1) partial agonist with EC50 of 16.9 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    STD-101-D1 is a novel brain permeable, G protein-biased beta-1 adrenergic receptor (ADRB1) partial agonist with EC50 of 16.9 nM.
    STD-101-D1 engages very little beta-arrestin recruitment compared to the unbiased agonist isoproterenol.
    STD-101-D1 also inhibits the acute peripheral and CNS TNFα response induced by LPS both in vitro and in vivo.

    物理化学性质&存储条件

    分子量 333.384
    分子式 C18H23NO5
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-4-(2-hydroxy-3-((2-(2-methoxyphenoxy)ethyl)amino)propoxy)phenol

    参考文献

    1. Yi B, et al. PLoS One. 2017 Jul 26;12(7):e0180319.

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