ST2825 (ST-2825) | MyD88 inhibitor | Probechem Biochemicals

Chemical Structure : ST2825

CAS No.: 894787-30-5

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ST2825 (ST-2825, ST2825)

货号: PC-45910Not For Human Use, Lab Use Only.

ST-2825 (ST2825) is a synthetic peptido-mimetic compound that inhibits MyD88 dimerization in a TIR-dependent manner.

规格	价格	库存
1 mg	￥2280	In stock
5 mg	￥5480	In stock
10 mg		Get quote
25 mg		Get quote

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生物&药学活性

ST-2825 (ST2825) is a synthetic peptido-mimetic compound that inhibits MyD88 dimerization in a TIR-dependent manner.
ST-2825 interferes with recruitment of IRAK1 and IRAK4 by MyD88, causing inhibition of IL-1beta-mediated activation of NF-kappaB transcriptional activity.
ST-2825 inhibits IL-1beta-induced production of IL-6 in treated mice, suppresses B cell proliferation and differentiation into plasma cells in response to CpG-induced activation of TLR9.
ST-2825 is orally active.

物理化学性质&存储条件

分子量	591.506
分子式	C27H28Cl2N4O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Spiro[pyrrolidine-2,7'(6'H)-[2H]pyrrolo[2,1-b][1,3]thiazine]-4'-carboxamide, 1-[2-[4-[[2-(2,4-dichlorophenoxy)acetyl]amino]phenyl]acetyl]tetrahydro-6'-oxo-, (2R,4'R,8'aR)-

参考文献

1. Loiarro M, et al. J Leukoc Biol. 2007 Oct;82(4):801-10.

2. Van Tassell BW, et al. Pharmacol. 2011 Feb;57(2):272.

3. Capolunghi F, et al. Rheumatology (Oxford). 2010 Dec;49(12):2281-9.

ST2825 (ST-2825, ST2825)

生物&药学活性

物理化学性质&存储条件

参考文献

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ST2825 (ST-2825, ST2825)

生物&药学活性

物理化学性质&存储条件

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