SSTC3 | CK1α activator | Probechem Biochemicals

Chemical Structure : SSTC3

CAS No.: 1242422-09-8

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SSTC3 (CK1α activator SSTC3, SSTC-3)

货号: PC-60387Not For Human Use, Lab Use Only.

SSTC3 is a novel small-molecule CK1α activator with EC50 of 30 nM (WNT-driven reporter gene assay), Kd of 32 nM.

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生物&药学活性

SSTC3 is a novel small-molecule CK1α activator with EC50 of 30 nM (WNT-driven reporter gene assay), Kd of 32 nM.
SSTC3 has better pharmacokinetic properties than pyrvinium (Cat# PC-60383), attenuates the growth of such Apc mutant organoids with EC50 of 2.9 uM.
SSTC3 decreases the viability of the WNT-dependent cell lines (EC50 = 132, 63, and 123 nM for HT29, SW403, and HCT116 cells, respectively), inhibits the growth of CRC xenografts in mice.
SSTC3 also attenuates the growth of patient-derived metastatic CRC xenograft, with minimal gastrointestinal toxicity compared to other classes of WNT inhibitors.

物理化学性质&存储条件

分子量	518.529
分子式	C23H17F3N4O3S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(N-methyl-N-(4-(trifluoromethyl)phenyl)sulfamoyl)-N-(4-(pyridin-2-yl)thiazol-2-yl)benzamide

参考文献

1. Li B, et al. Sci Signal. 2017 Jun 27;10(485). pii: eaak9916.

SSTC3 (CK1α activator SSTC3, SSTC-3)

生物&药学活性

物理化学性质&存储条件

参考文献

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SSTC3 (CK1α activator SSTC3, SSTC-3)

生物&药学活性

物理化学性质&存储条件

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