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首页-小分子抑制剂&激动剂-Wnt/Notch/Hedgehog-Casein Kinase-SR-4133
SR-4133

Chemical Structure : SR-4133

CAS No.:

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SR-4133 (SR4133)

货号: PC-20823Not For Human Use, Lab Use Only.

SR-4133 (SR4133) is a potent and highly selective CK1ε isoform inhibitor with IC50 of 58 nM, no significant acitivity agianst CK1δ (IC50>10,000 nM).

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

SR-4133 (SR4133) is a potent and highly selective CK1ε isoform inhibitor with IC50 of 58 nM, no significant acitivity agianst CK1δ (IC50>10,000 nM).
SR-4133 blocks the phosphorylation of T37/46, S65, and T70 of 4E-BP1 in T24 cells.
SR-4133 displays nanomolar growth inhibition of bladder cancer cells and inhibit the phosphorylation of 4E-BP1 in T24 cells, which is a direct downstream effector of CK1ε.

物理化学性质&存储条件

分子量 512.52
分子式 C27H22F2N8O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

FC1=CC=C2NC(CNC3=C4N=CN(C5=CC=C6C=CC=CC6=C5)C4=NC(N7CCOCC7)=N3)=NC2=C1F

参考文献

1. Jun Yong Choi, et al. J Med Chem. 2023 May 19. doi: 10.1021/acs.jmedchem.2c01180.

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