SN79 dihydrochloride |CAS:1121928-95-7 Probechem Biochemicals

Chemical Structure : SN79 dihydrochloride

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SN79 dihydrochloride (Sigma receptor ligand SN79)

货号: PC-35890Not For Human Use, Lab Use Only.

SN79 dihydrochloride (Sigma receptor ligand SN79) is a putative sigma receptor (σ receptor) antagonist with nanomolar affinity and selectivity for σ receptors over 57 other binding sites.

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生物&药学活性

SN79 dihydrochloride (Sigma receptor ligand SN79) is a putative sigma receptor (σ receptor) antagonist with nanomolar affinity and selectivity for σ receptors over 57 other binding sites.
SN79 shows activity against methamphetamine-induced neurotoxicity in vivo.
SN79 blocks methamphetamine-induced microglial activation and cytokine upregulation.

物理化学性质&存储条件

分子量	484.393
分子式	C23H28Cl2FN3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-acetyl-3-(4-(4-(4-fluorophenyl)piperazin-1-yl)butyl)benzo[d]oxazol-2(3H)-one dihydrochloride

参考文献

1. Nicholson HE, et al. J Pharmacol Exp Ther. 2018 Dec 7. pii: jpet.118.253484. doi: 10.1124/jpet.118.253484.

2. Kaushal N, et al. AAPS J. 2011 Sep;13(3):336-46. doi: 10.1208/s12248-011-9274-9.

3. Seminerio MJ, et al. Eur J Pharmacol. 2012 Sep 15;691(1-3):103-9. doi: 10.1016/j.ejphar.2012.07.029.

4. Kaushal N, et al. Eur J Pharmacol. 2014 Feb 5;724:193-203.

SN79 dihydrochloride (Sigma receptor ligand SN79)

生物&药学活性

物理化学性质&存储条件

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SN79 dihydrochloride (Sigma receptor ligand SN79)

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物理化学性质&存储条件

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