SN79 |CAS:1122147-66-3 Probechem Biochemicals

Chemical Structure : SN79

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SN79 (SN 79;SN-79)

货号: PC-60749Not For Human Use, Lab Use Only.

SN79 is a potent, orally active sigma receptor antagonist with Ki of 27 and 7 nM for σ1 and σ2, respectively.

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生物&药学活性

SN79 is a potent, orally active sigma receptor antagonist with Ki of 27 and 7 nM for σ1 and σ2, respectively.
SN79 also exhibits moderate affinity for serotonin transporters and norepinephrine transporters, displays a moderate affinity for 5-HT2 receptors and negligible affinity, does not inhibit major cytochrome P450 enzymes.
SN79 significantly attenuates cocaine-induced convulsions and locomotor activity in mice, also significantly attenuates the development and expression of the sensitized response to repeated cocaine exposures.

物理化学性质&存储条件

分子量	411.477
分子式	C23H26FN3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-acetyl-3-(4-(4-(4-fluorophenyl)piperazin-1-yl)butyl)benzo[d]oxazol-2(3H)-one

参考文献

1. Kaushal N, et al. AAPS J. 2011 Sep;13(3):336-46.

2. Seminerio MJ, et al. Eur J Pharmacol. 2012 Sep 15;691(1-3):103-9.

3. Kaushal N, et al. Eur Neuropsychopharmacol. 2013 Aug;23(8):960-71.

4. Kaushal N, et al. Eur J Pharmacol. 2014 Feb 5;724:193-203.

SN79 (SN 79;SN-79)

生物&药学活性

物理化学性质&存储条件

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SN79 (SN 79;SN-79)

生物&药学活性

物理化学性质&存储条件

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