SMNDC1 inhibitor 28

Chemical Structure : SMNDC1 inhibitor 28

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货号: PC-21062Not For Human Use, Lab Use Only.

SMNDC1 inhibitor 28 is a specific small molecule inhibitor targeting the dimethylarginine binding pocket of the SMNDC1 Tudor domain with IC50 of 0.5 uM, 30-fold selectivity for SMNDC1 over SMN.

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50 mg		Get quote
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1 g		Get quote

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生物&药学活性

SMNDC1 inhibitor 28 is a specific small molecule inhibitor targeting the dimethylarginine binding pocket of the SMNDC1 Tudor domain with IC50 of 0.5 uM, 30-fold selectivity for SMNDC1 over SMN.
SMNDC1 inhibitor 28 drastically alters protein-protein interactions and subcellular localization, causing splicing changes for SMNDC1-dependent genes.

物理化学性质&存储条件

分子量	466.56
分子式	C24H26N4O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(OC(C)(C)C)NCCNC(C1=CC=C(C(NC2=NC(C3=CC=CC=C3)=CS2)=O)C=C1)=O

参考文献

1. Lennart Enders, et al. Nat Commun. 2023 Aug 16;14(1):4504.