SLF1081851 | Spns2 inhibitor | Probechem Biochemicals

Chemical Structure : SLF1081851

CAS No.: 2763730-97-6

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SLF1081851 (SLF 1081851)

货号: PC-38763Not For Human Use, Lab Use Only.

SLF1081851 is a potent, in vivo-active inhibitor of S1P transporter spinster homologue 2 (Spns2), inhibits S1P release with IC50 of 1.93 uM in HeLa cells.

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5 mg	￥1280	In stock
10 mg	￥1980	In stock
25 mg	￥3580	In stock
50 mg	￥5580	In stock
100 mg		Get quote

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生物&药学活性

SLF1081851 is a potent, in vivo-active inhibitor of S1P transporter spinster homologue 2 (Spns2), inhibits S1P release with IC50 of 1.93 uM in HeLa cells.
Administration of SLF1081851 to mice and rats drove significant decreases in circulating lymphocyte counts and plasma S1P concentrations, recapitulating the phenotype observed in mice made deficient in Spns2.
SLF1081851 shows the potential for development and use as a probe to investigate Spns2 biology and to determine the potential of Spns2 as a drug target.

物理化学性质&存储条件

分子量	343.515
分子式	C21H33N3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(3-(4-decylphenyl)-1,2,4-oxadiazol-5-yl)propan-1-amine

参考文献

1. Russell Fritzemeier, et al. J Med Chem. 2022 Jun 9;65(11):7656-7681.

SLF1081851 (SLF 1081851)

生物&药学活性

物理化学性质&存储条件

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SLF1081851 (SLF 1081851)

生物&药学活性

物理化学性质&存储条件

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