SK2188 | Aurora A PROTAC | Probechem Biochemicals

Chemical Structure : SK2188

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SK2188 (SK-2188)

货号: PC-24083Not For Human Use, Lab Use Only.

SK2188 is a potent, highly selective PROTAC degrader of Aurora A with DC50 of 3.9 nM and Dmax of 89% in NGP neuroblastoma cells, induces subsequent reduction of MYCN.

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生物&药学活性

SK2188 is a potent, highly selective PROTAC degrader of Aurora A with DC50 of 3.9 nM and Dmax of 89% in NGP neuroblastoma cells, induces subsequent reduction of MYCN.
SK2188 displays excellent AURKA binding and degradation selectivity.
SK2188 potently inhibits cell growth with IC50 of 31.9 nM in NGP cells, triggers apoptosis and results in elevated DNA damage and replicative stress markers.
SK2188 anti-proliferative activity varies across NB cell lines and patient-derived organoids.

物理化学性质&存储条件

分子量	893.38
分子式	C43H46ClFN6O10S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1r,4r)-4-(3-chloro-2-fluorophenoxy)-N-(2-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)ethoxy)ethoxy)ethoxy)ethyl)-1-((6-(thiazol-2-ylamino)pyridin-2-yl)methyl)cyclohexane-1-carboxamide

参考文献

1. Rishfi M, et al. Eur J Med Chem. 2023 Feb 5;247:115033.

SK2188 (SK-2188)

生物&药学活性

物理化学性质&存储条件

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SK2188 (SK-2188)

生物&药学活性

物理化学性质&存储条件

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