SK-575 (SK575)

Chemical Structure : SK-575

CAS No.: 2523016-96-6

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货号: PC-27298Not For Human Use, Lab Use Only.

SK-575 is a highly potent, selective PARP1 PROTAC degrader with IC50 of 2.3 nM, potently inhibits cancer cell growth of bearing BRCA1/2 mutations and induces potent and specific degradation of PARP1 in various human cancer cells even at low picomolar concentrations.

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2 mg	￥1580	In stock
5 mg	￥2580	In stock
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25 mg		Get quote

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生物&药学活性

SK-575 is a highly potent, selective PARP1 PROTAC degrader with IC50 of 2.3 nM, potently inhibits cancer cell growth of bearing BRCA1/2 mutations and induces potent and specific degradation of PARP1 in various human cancer cells even at low picomolar concentrations.

物理化学性质&存储条件

分子量	876.99
分子式	C47H53FN8O8
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)-12-(4-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoyl)piperazin-1-yl)-12-oxododecanamide

参考文献

1. Chaoguo Cao, et al. J Med Chem. 2020 Oct 8;63(19):11012-11033.

SK-575 (SK575)

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物理化学性质&存储条件

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SK-575 (SK575)

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