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首页-抗体药物偶连体和PROTACs-PROTAC-SJF620
SJF620

Chemical Structure : SJF620

CAS No.: 2376187-16-3

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SJF620 (SJF 620, SJF-620)

货号: PC-22653Not For Human Use, Lab Use Only.

SJF620 is a potent, selective, CRBN-recruiting BTK PROTAC degrader with DC50 of 7.9 nM in NAMALWA cells (Dmax 95%).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

SJF620 is a potent, selective, CRBN-recruiting BTK PROTAC degrader with DC50 of 7.9 nM in NAMALWA cells (Dmax 95%).
SJF620 displays superior pharmacokinetic profiles relative to MT-802, with exhibiting a more robust clearance and exposure profile.

物理化学性质&存储条件

分子量 760.85
分子式 C41H44N8O7
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-(5-(2-(2-(2-(4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)ethoxy)ethoxy)ethoxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione

参考文献

1. Jaime-Figueroa S, et al. Bioorg Med Chem Lett. 2020 Feb 1;30(3):126877.

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