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首页-抗体药物偶连体和PROTACs-PROTAC-SJ44236
SJ44236

Chemical Structure : SJ44236

CAS No.:

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SJ44236 (SJ-44236)

货号: PC-23841Not For Human Use, Lab Use Only.

SJ44236 is a highly potent, selective and orally bioavailable BET PROTAC with BRD4 DC50 of 0.127 nM in MV4-11 cells, induces pronounced degradation of BRD2, BRD3 and BRD4.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

SJ44236 is a highly potent, selective and orally bioavailable BET PROTAC with BRD4 DC50 of 0.127 nM in MV4-11 cells, induces pronounced degradation of BRD2, BRD3 and BRD4.
SJ44236 displays potent antiproliferative effect in MV4–11 and HD-MB03 cell lines.
SJ44236 shows improved pharmacokinetic profile over SJ995973.

物理化学性质&存储条件

分子量 753.36
分子式 C40H45ClN8O3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-(4-(4-((1-(2-((S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetyl)piperidin-4-yl)methyl)piperazin-1-yl)phenyl)piperidine-2,6-dione

参考文献

1. Actis M, et al. J Med Chem. 2025 Jan 15. doi: 10.1021/acs.jmedchem.4c02709.

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