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首页-抗体药物偶连体和PROTACs-PROTAC-SJ1008030
SJ1008030

Chemical Structure : SJ1008030

CAS No.: 2863634-96-0

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SJ1008030 (SJ 1008030)

货号: PC-49144Not For Human Use, Lab Use Only.

SJ1008030 is a potent, specific JAK2-degrading, GSPT1-sparing PROTAC, potently inhibits MHH-CALL-4 cell growth with IC50 of 5.4 nM.

规格 价格 库存 数量
2 mg ￥3980 In stock
5 mg ￥5980 In stock
10 mg ￥8980 In stock
25 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

SJ1008030 is a potent, specific JAK2-degrading, GSPT1-sparing PROTAC, potently inhibits MHH-CALL-4 cell growth with IC50 of 5.4 nM.
SJ1008030 potently kills CRLF2r cell lines MHH–CALL-4 and KOPN49, with less potency in MHH–CALL-2 (hypodiploid ALL) and KOPN75 (PAX5-ETV6) cells and the least efficacy in 697 (TCF3-PBX1) and NALM-6 (DUX4-rearranged ALL) cells.
SJ1008030 shows antileukemic efficacy in patient-derived xenograft ALL cells.

物理化学性质&存储条件

分子量 873.950
分子式 C42H43N13O7S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-((4-(1-(3-(cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N-(2-(4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperazin-1-yl)ethyl)benzamide

参考文献

1. Yunchao Chang, et al. Blood. 2021 Dec 9;138(23):2313-2326.

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