SINCRO |CAS:1494619-28-1 Probechem Biochemicals

Chemical Structure : SINCRO

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SINCRO (STING agonist SINCRO)

货号: PC-35434Not For Human Use, Lab Use Only.

SINCRO is a novel anti-cancer compound that can activate the cytosolic DNA-sensing STING signaling pathway leading to the induction of type I interferon (IFN) genes.

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生物&药学活性

SINCRO is a novel anti-cancer compound that can activate the cytosolic DNA-sensing STING signaling pathway leading to the induction of type I interferon (IFN) genes。
SINCRO (STING-mediated interferon-inducing and cytotoxic reagent, original) shows a STING-independent cytotoxic activity against cancer cells, SINCRO does not evoke DNA double-strand break or caspase-3 cleavage, induces cell death in a manner different from conventional apoptosis-inducing pathways。
SINCRO significantly attenuates in vivo tumor growth by both type I IFN-dependent and independent mechanisms.

物理化学性质&存储条件

分子量	504.723
分子式	C30H44N6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-{3-[(1,4'-bipiperidin)-1'-yl]propyl}-6-[4-(4-methylpiperazin-1-yl)phenyl]picolinamide

参考文献

1. Kimura Y, et al. Cancer Sci. 2018 Jul 7. doi: 10.1111/cas.13726.

SINCRO (STING agonist SINCRO)

生物&药学活性

物理化学性质&存储条件

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SINCRO (STING agonist SINCRO)

生物&药学活性

物理化学性质&存储条件

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