欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-抗体药物偶连体和PROTACs-PROTAC-SIAIS361034
SIAIS361034

Chemical Structure : SIAIS361034

CAS No.: 2641287-90-1

加入收藏

SIAIS361034 (SIAIS 361034)

货号: PC-23129Not For Human Use, Lab Use Only.

SIAIS361034 is a potent, selective PROTAC degrader of Bcl-xL, selectively degrades Bcl-xL and significantly inhibits the Hh pathway activity SIAIS361034 with IC50 of 120 nM.

规格 价格 库存 数量
25 mg Get quote
50 mg Get quote
100 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

SIAIS361034 is a potent, selective PROTAC degrader of Bcl-xL, selectively degrades Bcl-xL and significantly inhibits the Hh pathway activity SIAIS361034 with IC50 of 120 nM.
SIAIS361034 binds to Bcl-xL and Bcl-2 with Ki values of 37.27 nM and 15.09 nM, respectively, but exhibits little affinity to Mcl-1.
SIAIS361034 potently degrades Bcl-xL via CRBN E3 ubiquitin ligase and ubiquitin proteasome system.
SIAIS361034 significantly degrades Bcl-xL and did not change the levels of Bcl-2 and Mcl-1.
SIAIS361034 inhibits the Hh signaling pathway by disabling Bcl-xL/Sufu interaction.
SIAIS361034 possesses the ability of combating resistance to Smo inhibitors caused by Smo mutations and Gli2 amplification.
SIAIS361034 10 mg/kg oral (p.o.) administration retards hair growth in a depilatory model by inhibiting the Hh pathway activity.

物理化学性质&存储条件

分子量 1159.78
分子式 C58H66ClF3N8O8S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-(4-((4'-chloro-4,4-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-N-((4-((3-(4-(5-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)pent-4-yn-1-yl)piperazin-1-yl)propyl)amino)-3-((trifluoromethyl)sulfonyl)phenyl)sulfonyl)benzamide

参考文献

1. Shaoqing Zhang, et al. Theranostics. 2022 Oct 24;12(17):7476-7490.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: