SIAIS164018

Chemical Structure : SIAIS164018

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货号: PC-27487Not For Human Use, Lab Use Only.

SIAIS164018 is a potent, Brigatinib-based PROTAC degrader of multi-kinases ALK, EGFR, FAK, PYK2, PTK6 with IC50 of 2.5 nM and 6.6 nM against ALK and ALK (G1202R), respectively, promotes the ubiquitination and degradation of ALK, EGFR, FAK, PYK2 and PTK6, induces cell cycle arrest at the G1 phase and triggers cell apoptosis.

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生物&药学活性

物理化学性质&存储条件

分子量	883.34
分子式	C43H48ClN10O7P
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-((2-(4-(1-(4-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperidin-4-yl)piperazin-1-yl)-2-oxoethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

参考文献

1. Ren C, et al. J Med Chem. 2021 Jul 8;64(13):9152-9165.

2. Chu D, et al. Bioorg Med Chem. 2026 Mar;134:118521.

SIAIS164018

生物&药学活性

物理化学性质&存储条件

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SIAIS164018

生物&药学活性

物理化学性质&存储条件

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