SHR1032 | STING agonist | Probechem Biochemicals

Chemical Structure : SHR1032

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SHR1032 (SHR-1032)

货号: PC-38729Not For Human Use, Lab Use Only.

SHR1032 is a novel small molecule non-cyclic di-nucleotide STING agonist, exhibits significantly high affinity binding to STING and cellular reporter assay (EC50=30 nM).

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生物&药学活性

SHR1032 is a novel small molecule non-cyclic di-nucleotide STING agonist, exhibits significantly high affinity binding to STING and cellular reporter assay (EC50=30 nM).
SHR1032 displays high potency and specificity towards major human STING alleles and activates cGAS-STING signaling.
SHR1032 induces strong in vivo anti-tumor immunity, suppresss AML THP1-STING-R232 cell growth (GI50=23 nM), MV4-11 and MOLM-16 cells are very sensitive to SHR1032 with GI50s of 1.0 nM and 2.6 nM, respectively).
SHR1032 induces de novo apoptotic genes leading to cell death in AML cells.
SHR1032 has much higher activity in human cells with different STING haplotypes and robustly induces interferon β (IFNβ) production, compared to ADU-S100.

物理化学性质&存储条件

分子量	736.794
分子式	C36H40N12O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-3-(3-(5-carbamoyl-2-(1-ethyl-3-methyl-1H-pyrazole-5-carboxamido)-7-methoxy-1H-benzo[d]imidazol-1-yl)propyl)-2-(1-ethyl-3-methyl-1H-pyrazole-5-carboxamido)-3,4-dihydro-5-oxa-1,2a-diazaacenaphthylene-7-carboxamide

参考文献

1. Chunying Song, et al. Sci Rep. 2022 May 20;12(1):8579.

SHR1032 (SHR-1032)

生物&药学活性

物理化学性质&存储条件

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SHR1032 (SHR-1032)

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物理化学性质&存储条件

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