SHP2 PROTAC R1-5C

Chemical Structure : SHP2 PROTAC R1-5C

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货号: PC-38182Not For Human Use, Lab Use Only.

SHP2 PROTAC R1-5C is a potent and highly selective SHP2 PROTAC created by conjugating RMC-4550 with pomalidomide using a PEG linker, with a low nanomolar DC50.

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生物&药学活性

SHP2 PROTAC R1-5C is a potent and highly selective SHP2 PROTAC created by conjugating RMC-4550 with pomalidomide using a PEG linker, with a low nanomolar DC50.
SHP2 PROTAC R1-5C is highly selective for SHP2, induces degradation of SHP2 in leukemic cells at submicromolar concentrations.
SHP2 PROTAC R1-5C inhibits MAPK signaling, and suppresses cancer cell growth.
SHP2 PROTACs serve as an alternative strategy for targeting ERK-dependent cancers and are useful tools alongside allosteric inhibitors for dissecting the mechanisms by which SHP2 exerts its oncogenic activity.

物理化学性质&存储条件

分子量	1119.057
分子式	C52H69Cl2N7O16
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(23-(4-(5-((3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)-6-(hydroxymethyl)-3-methylpyrazin-2-yl)-2,3-dichlorophenoxy)-3,6,9,12,15,18,21-heptaoxatricosyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide

参考文献

1. Vidyasiri Vemulapalli, et al. Biochemistry. 2021 Aug 31;60(34):2593-2609.

SHP2 PROTAC R1-5C

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SHP2 PROTAC R1-5C

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