SHP2-D26 | SHP2 PROTAC | Probechem Biochemicals

Chemical Structure : SHP2-D26

CAS No.: 2458219-65-1

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SHP2-D26 (SHP2D26)

货号: PC-38185Not For Human Use, Lab Use Only.

SHP2-D26 is a potent and effective SHP2 degrader (PROTAC) with DC50 of 6.0 and 2.6 nM in esophageal cancer KYSE520 and acute myeloid leukemia MV4.

规格	价格	库存
1 mg	￥3580	In stock
5 mg	￥5980	In stock
10 mg		Get quote
25 mg		Get quote

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生物&药学活性

SHP2-D26 is a potent and effective SHP2 degrader (PROTAC) with DC50 of 6.0 and 2.6 nM in esophageal cancer KYSE520 and acute myeloid leukemia MV4;11 cells, respectively。
SHP2-D26 is >30-times more potent in inhibition of phosphorylation of extracellular signal-regulated kinase (ERK) and of cell growth than SHP099, a potent SHP2 inhibitor, in KYSE520 and MV4;11 cancer cell lines.

物理化学性质&存储条件

分子量	1115.896
分子式	C56H79ClN12O6S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S,4R)-1-((S)-2-(9-(4-(4-((3-((3-amino-5-(4-amino-4-methylpiperidin-1-yl)pyrazin-2-yl)thio)-2-chlorophenyl)amino)-4-oxobutanoyl)piperazin-1-yl)nonanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide

参考文献

1. Wang M, et al. J Med Chem. 2020 Jul 23;63(14):7510-7528.

SHP2-D26 (SHP2D26)

生物&药学活性

物理化学性质&存储条件

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SHP2-D26 (SHP2D26)

生物&药学活性

物理化学性质&存储条件

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