SF2768 | Copper chelator, Antifungal | Probechem Biochemicals

Chemical Structure : SF2768

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SF2768 (SF-2768, RK-276A)

货号: PC-24826Not For Human Use, Lab Use Only.

SF2768 (RK-276A) is a diisonitrile antibiotic and specific copper chelator, exhibits potent antifungal activity against C. albicans with IC50 of 0.01 uM.

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生物&药学活性

SF2768 (RK-276A) is a diisonitrile antibiotic and specific copper chelator, exhibits potent antifungal activity against C. albicans with IC50 of 0.01 uM.
SF2768 is almost equivalent to that of existing antifungal drugs, such as amphotericin B and micafungin.
also showed antifungal activity against Aspergillus fumigatus and Staphylococcus aureus at sub-µM without any cytotoxicity to HL-60 cells up to 30 µM (selectivity index > 3,000).
SF2768 suppressed the morphological changes in C. albicans from hyphal to yeast form.
SF2768 suppressed the yeast budding of C. albicans.
SF2768 can specifically bind to copper in a stoichiometry of 2:1.

物理化学性质&存储条件

分子量	336.39
分子式	C16H24N4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3R)-3-cyano-N-(((2S,5S)-5-((R)-3-cyanobutanamido)-6-hydroxytetrahydro-2H-pyran-2-yl)methyl)butanamide

参考文献

1. Wang L, et al. ACS Chem Biol. 2017 Dec 15;12(12):3067-3075.

2. Futamura Y, et al. Antimicrob Agents Chemother. 2025 May 7;69(5):e0003325.

SF2768 (SF-2768, RK-276A)

生物&药学活性

物理化学性质&存储条件

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SF2768 (SF-2768, RK-276A)

生物&药学活性

物理化学性质&存储条件

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