SB-423557 | CaSR antagonist | Probechem Biochemicals

Chemical Structure : SB-423557

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SB-423557 (SB423557)

货号: PC-26411Not For Human Use, Lab Use Only.

SB-423557 is the orally bioavailable ethyl ester precursor of SB-423562, which is a potent, selective and short-acting calcium-sensing receptor (CaSR) antagonist with IC50 of 73 nM.

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生物&药学活性

SB-423557 is the orally bioavailable ethyl ester precursor of SB-423562, which is a potent, selective and short-acting calcium-sensing receptor (CaSR) antagonist with IC50 of 73 nM.
SB-423557 exhibits CaSR antagonist activity in vitro with IC50 of 520 nM.
SB-423557 elicits transient PTH release from the parathyroid gland.
SB-423557 promoted bone formation and improved parameters of bone strength at lumbar spine, proximal tibia and midshaft femur in ovariectomized rat model of bone loss.

物理化学性质&存储条件

分子量	464.61
分子式	C28H36N2O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	ethyl (R)-3-(4-cyano-3-(3-((1-(2,3-dihydro-1H-inden-2-yl)-2-methylpropan-2-yl)amino)-2-hydroxypropoxy)phenyl)propanoate

参考文献

1. Sanjay Kumar, et al. Bone. 2010 Feb;46(2):534-42.

SB-423557 (SB423557)

生物&药学活性

物理化学性质&存储条件

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SB-423557 (SB423557)

生物&药学活性

物理化学性质&存储条件

参考文献

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