SAS-0132 | Sigma 2 Receptor ligand | Probechem Biochemicals

Chemical Structure : SAS-0132

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SAS-0132 (SAS0132, SAS 132)

货号: PC-61100Not For Human Use, Lab Use Only.

SAS-0132 (SAS132) is a novel potent, subtype-selective, brain penetrant sigma 2 receptor/PGRMC1 ligand with Ki of 90 nM, 9-fold selectivity over sigma 1 receptors.

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生物&药学活性

SAS-0132 (SAS132) is a novel potent, subtype-selective, brain penetrant sigma 2 receptor/PGRMC1 ligand with Ki of 90 nM, 9-fold selectivity over sigma 1 receptors.
SAS-0132 also exhibits low off-target affinity for most CNS-relevant targets, including opioid, adrenergic, nACR, mAChR, and NMDA receptors.
SAS-0132 modulates intracellular Ca2+ levels in human SK-N-SH neuroblastoma cells, and is neuroprotective in a C. elegans model of amyloid precursor protein-mediated neurodegeneration, improves cognitive performance in transgenic mouse model of AD.

物理化学性质&存储条件

分子量	391.515
分子式	C24H29N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	benzyl (1R,5S)-8-(4-methylpiperazin-1-yl)-1,3,4,5-tetrahydro-2H-1,5-methanobenzo[c]azepine-2-carboxylate

参考文献

1. Yi B, et al. J Neurochem. 2017 Feb;140(4):561-575.

2. Sahn JJ, et al. ACS Chem Neurosci. 2017 Aug 16;8(8):1801-1811.

3. Sahn JJ, et al. ChemMedChem. 2016 Mar 17;11(6):556-61.

SAS-0132 (SAS0132, SAS 132)

生物&药学活性

物理化学性质&存储条件

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SAS-0132 (SAS0132, SAS 132)

生物&药学活性

物理化学性质&存储条件

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