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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Parasite-SAL-0010003
SAL-0010003

Chemical Structure : SAL-0010003

CAS No.: 521297-38-1

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SAL-0010003

货号: PC-23657Not For Human Use, Lab Use Only.

SAL-0010003 is a fast-acting and potent Plasmodium falciparum PDEβ inhibitor with IC50 of 17.3 nM for cGMP hydrolysis in crude gametocyte membrane preparations, and EC50 of 327 nM for 3D7 blood stage.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

SAL-0010003 is a fast-acting and potent Plasmodium falciparum PDEβ inhibitor with IC50 of 17.3 nM for cGMP hydrolysis in crude gametocyte membrane preparations, and EC50 of 327 nM for 3D7 blood stage.

物理化学性质&存储条件

分子量 304.30
分子式 C15H14F2N4O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5-(2,4-difluorobenzyl)-3-isopropyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one

参考文献

1. Gomez-Gonzalez PJ, et al. Sci Adv. 2024 Dec 6;10(49):eadq1383.

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