S1RA (E-52862) | Sigma 1 receptor antagonist | Probechem Biochemicals

Chemical Structure : S1RA

CAS No.: 878141-96-9

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S1RA (E-52862, E52862)

货号: PC-45417Not For Human Use, Lab Use Only.

S1RA (E-52862) is a potent and selective sigma-1 receptor (S1R) antagonist with Ki of 17 nM.

规格	价格	库存
5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥1980	In stock
50 mg	￥3280	In stock
100 mg		Get quote

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生物&药学活性

S1RA (E-52862) is a potent and selective sigma-1 receptor (S1R) antagonist with Ki of 17 nM.
S1RA (E-52862) shows excellent selectivity over sigma-2 receptor (Ki>1 uM).
S1RA (E-52862) shows high activity in the mouse capsaicin model of neurogenic pain, exerts dose-dependent antinociceptive effects in several neuropathic pain models.

物理化学性质&存储条件

分子量	337.4155
分子式	C20H23N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Morpholine, 4-[2-[[5-methyl-1-(2-naphthalenyl)-1H-pyrazol-3-yl]oxy]ethyl]-

参考文献

1. Díaz JL, et al. J Med Chem. 2012 Oct 11;55(19):8211-24.

2. Romero L, et al. Br J Pharmacol. 2012 Aug;166(8):2289-306.

3. Nieto FR, et al. J Pain. 2012 Nov;13(11):1107-21.

S1RA (E-52862, E52862)

生物&药学活性

物理化学性质&存储条件

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S1RA (E-52862, E52862)

生物&药学活性

物理化学性质&存储条件

参考文献

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