欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-Others-Small GTPase-Rhosin hydrochloride
Rhosin hydrochloride

Chemical Structure : Rhosin hydrochloride

CAS No.: 1281870-42-5

加入收藏

Rhosin hydrochloride (G04 hydrochloride)

货号: PC-43132Not For Human Use, Lab Use Only.

Rhosin (G04) is a potent, specific RhoA subfamily Rho GTPases inhibitor that specifically binds to RhoA to inhibit GEF reaction of RhoA with Kd of 0.4 uM, does not interact with Cdc42 or Rac1, nor the LARG.

规格 价格 库存 数量
5 mg ￥1880 In stock
10 mg ￥2980 In stock
25 mg ￥4880 In stock
50 mg Get quote
100 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Rhosin (G04) hydrochloride is a potent, specific RhoA subfamily Rho GTPases inhibitor that specifically binds to RhoA to inhibit GEF reaction of RhoA with Kd of 0.4 uM, does not interact with Cdc42 or Rac1, nor the LARG.
Rhosin specifically inhibits GEF activation of RhoA in vitro and in cells and can potently suppress breast cancer cell proliferation and invasion and induce neurite outgrowth in PC12 cells.
Rhosin strongly inhibits RhoA-GTP formation in NIH 3T3 cells (EC50=10-30 uM), reduces RhoA and p-MLC1 activities of MCF7 cell-derived mammospheres (EC50=30-50 uM).
Rhosin suppresses invasion of mammary epithelial cells, induces neurite outgrowth of PC12 cells in synergy with NGF.

物理化学性质&存储条件

分子量 394.8575
分子式 C20H19ClN6O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

D-Tryptophan, 2-(6-quinoxalinylmethylene)hydrazide, hydrochloride (1:1)

参考文献

1. Shang X, et al. Chem Biol. 2012 Jun 22;19(6):699-710.

2. Shang X, et al. Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):3155-60.

3. Yoon C, et al. Clin Cancer Res. 2016 Feb 15;22(4):971-83.

4. Duan X, et al. Cell Cycle. 2016;15(3):471-7.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: