Rheb inhibitor NR1 |CAS: 2216763-38-9 Probechem Biochemicals

Chemical Structure : Rheb inhibitor NR1

CAS No.: 2216763-38-9

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Rheb inhibitor NR1

货号: PC-62515Not For Human Use, Lab Use Only.

Rheb inhibitor NR1 is a small molecule that binds Rheb in the switch II domain (IC50=2.1 uM, Kd=1.5 uM) and selectively blocks mTORC1 signaling, potently inhibits mTORC1 driven phosphorylation of S6K1 but does not inhibit phosphorylation of AKT or ERK.

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5 mg	￥1880	In stock
10 mg	￥2880	In stock
25 mg	￥4580	In stock
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100 mg		Get quote

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生物&药学活性

Rheb inhibitor NR1 is a small molecule that binds Rheb in the switch II domain (IC50=2.1 uM, Kd=1.5 uM) and selectively blocks mTORC1 signaling, potently inhibits mTORC1 driven phosphorylation of S6K1 but does not inhibit phosphorylation of AKT or ERK.
In contrast to rapamycin, NR1 does not cause inhibition of mTORC2 upon prolonged treatment, potently and selectively inhibits mTORC1 in mouse kidney and muscle in vivo.

物理化学性质&存储条件

分子量	578.302
分子式	C25H19BrCl2N2O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-bromo-6-((3,4-dichlorophenyl)thio)-1-(4-(dimethylcarbamoyl)benzyl)-1H-indole-2-carboxylic acid

参考文献

1. Mahoney SJ, et al. Nat Commun. 2018 Feb 7;9(1):548.

Rheb inhibitor NR1

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物理化学性质&存储条件

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Rheb inhibitor NR1

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