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首页-小分子抑制剂&激动剂-Immunology/Inflammation-STING-Rhamnocitrin
Rhamnocitrin

Chemical Structure : Rhamnocitrin

CAS No.: 569-92-6

Rhamnocitrin

货号: PC-23402Not For Human Use, Lab Use Only.

Rhamnocitrin is a flavonoid with anti-oxidant, anti-inflammatory and an-tiatherosclerosis activity, also shows antiviral activity against influenza virus H3N2 by inhibiting cGAS/STING pathway.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Rhamnocitrin is a flavonoid with anti-oxidant, anti-inflammatory and an-tiatherosclerosis activity, also shows antiviral activity against influenza virus H3N2 by inhibiting cGAS/STING pathway.
Rhamnocitrin shows antiviral effect and anti-apoptosis on influenza virus A/Aichi/2/1968 (H3N2) in MDCK cells and A549 cells.
Rhamnocitrin has good binding activity with the target proteins cGAS and STING (Kd=2.6 uM).
Rhamnocitrin could reduce type I IFN and proinflammatory cytokines production by inhibiting the cGAS/STING pathway.

物理化学性质&存储条件

分子量 300.27
分子式 C16H12O6
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3,5-Dihydroxy-2-(4-hydroxyphenyl)-7-methoxy-4H-chromen-4-one

参考文献

1. Zexing Chen, et al. Sci Rep. 2024 Nov 16;14(1):28287.

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