Revefenacin |CAS:864750-70-9 Probechem Biochemicals

Chemical Structure : Revefenacin

CAS No.: 864750-70-9

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Revefenacin (TD 4208;TD4208;GSK 1160724)

货号: PC-61043Not For Human Use, Lab Use Only.

Revefenacin (TD4208, GSK 1160724) is a novel potent, long-acting, lung-selective inhaled muscarinic antagonist that has high affinity at M3 receptor, demonstrates in vitro kinetic selectivity for M3 over M2 and no meaningful off-target activity.

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5 mg (Free Sample)	￥280	In stock
10 mg	￥1180	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
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生物&药学活性

Revefenacin (TD4208, GSK 1160724) is a novel potent, long-acting, lung-selective inhaled muscarinic antagonist that has high affinity at M3 receptor, demonstrates in vitro kinetic selectivity for M3 over M2 and no meaningful off-target activity.
Revefenacin produces sustained inhibition of acetylcholine-induced bronchoconstriction for up to 24 hours along with tiotropium and glycopyrronium.
Revefenacin has the potential to be a long-acting bronchodilator for once-daily treatment of respiratory diseases.

物理化学性质&存储条件

分子量	597.76
分子式	C35H43N5O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Biphenyl-2-ylcarbamic acid 1-(2-{[4-(4-carbamoylpiperidin-1-ylmethyl)benzoyl]methylamino}ethyl)piperidin-4-yl ester

参考文献

1. Pulido-Rios MT, et al. J Pharmacol Exp Ther. 2013 Aug;346(2):241-50.

2. Mastrodicasa MA, et al. Expert Opin Investig Drugs. 2017 Feb;26(2):161-174

3. Quinn D, et al. Pulm Pharmacol Ther. 2017 Oct 4. pii: S1094-5539(17)30119-0.

Revefenacin (TD 4208;TD4208;GSK 1160724)

生物&药学活性

物理化学性质&存储条件

参考文献

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Revefenacin (TD 4208;TD4208;GSK 1160724)

生物&药学活性

物理化学性质&存储条件

参考文献

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