Ran inhibitor M36 | RAN GTPase inhibitor | Probechem Biochemicals

Chemical Structure : Ran inhibitor M36

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Ran inhibitor M36 (Ran-IN-1)

货号: PC-26551Not For Human Use, Lab Use Only.

Ran inhibitor M36 (Ran-IN-1) is a specific small molecule inhibitor of Ran GTPase, inhibits Ran-GTP activation, has IC50 of 10.02 uM in clonogenic assays for TOV112D cell line.

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生物&药学活性

Ran inhibitor M36 (Ran-IN-1) is a specific small molecule inhibitor of Ran GTPase, inhibits Ran-GTP activation, has IC50 of 10.02 uM in clonogenic assays for TOV112D cell line.
M36 inhibited colony formation of TOV112D cells without affecting the ARPE cells.
M36 significantly induced the expression of NR1D1 in two aneuploid EOC cell lines (TOV112D and OV1946).
M36 mimics the effect of the loss of Ran regarding DDR.
M36 (200 mg/kg, i.p.) significantly delayed tumor growth in aggressive ovarian xenograft model.
M36 induces cell death in ex vivo ovarian cancer models, combination of M36 and Olaparib triggers synthetic lethality in EOC cells.

物理化学性质&存储条件

分子量	517.56
分子式	C27H26F3NO4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2R,3R,4R,5R)-3,4-bis((4-fluorobenzyl)oxy)-5-(((4-fluorobenzyl)oxy)methyl)tetrahydrofuran-2-carbothioamide

参考文献

1. Boudhraa Z, et al. Identification of a new inhibitor of Ran GTPase with therapeutic value in epithelial ovarian cancer. bioRxiv, 2025: 2025.03. 02.641080.

Ran inhibitor M36 (Ran-IN-1)

生物&药学活性

物理化学性质&存储条件

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Ran inhibitor M36 (Ran-IN-1)

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物理化学性质&存储条件

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