Rac1-IN-1 |CAS:627042-19-7 Probechem Biochemicals

Chemical Structure : Rac1-IN-1

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Rac1-IN-1

货号: PC-61469Not For Human Use, Lab Use Only.

Rac1-IN-1 is a selective small molecule Rac1 inhibitor that blocks Rac1-PAK1 complex formation with IC50 of 95±21 nM.

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25 mg		Get quote
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200 mg		Get quote

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生物&药学活性

Rac1-IN-1 is a selective small molecule Rac1 inhibitor that blocks Rac1-PAK1 complex formation with IC50 of 95±21 nM.
Rac1-IN-1 diminishes the EGF-induced Rac1 activation in CD18/HPAF cells with EC50 of 8.3±1.7 uM, has no inhibitory effect on either Cdc42 or RhoA in CD18/HPAF cells.
Rac1-IN-1 shows a 50% and 20% decrease in proliferation for AsPC-1 and CD18/HPAF cells at 25 uM.
Rac1-IN-1 also reduces migration of pancreatic cancer cells.

物理化学性质&存储条件

分子量	350.33
分子式	C19H14N2O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3-acetylphenyl)-5-(3-nitrophenyl)furan-2-carboxamide

参考文献

1. Arnst JL, et al. Oncotarget. 2017 May 23;8(21):34586-34600.

Rac1-IN-1

生物&药学活性

物理化学性质&存储条件

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Rac1-IN-1

生物&药学活性

物理化学性质&存储条件

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