RNF4 PROTAC RD12

Chemical Structure : RNF4 PROTAC RD12

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货号: PC-26975Not For Human Use, Lab Use Only.

RNF4 PROTAC RD12 is a first-in-class, selective Ring Finger Protein 4 (RNF4) PROTAC degrader, selectively degrades RNF4 through UPS and induces DNA damage.

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生物&药学活性

RNF4 PROTAC RD12 is a first-in-class, selective Ring Finger Protein 4 (RNF4) PROTAC degrader, selectively degrades RNF4 through UPS and induces DNA damage.
RD12 is capable of inducing RNF4 protein degradation in multiple HCC cell lines (HepG2, HCCLM6, Huh7).
RD12 displays profound antiproliferative activity both in vitro and in vivo.
RD12 elicits a significant anti-tumor effect in a HCC mouse model.

物理化学性质&存储条件

分子量	866.47
分子式	C47H52ClN5O7S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S,4R)-1-((S)-2-(4-(4-(4-(N-benzyl-2-chloroacetamido)phenoxy)phenoxy)butanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

参考文献

1. Hui Wan, et al. Eur J Med Chem. 2026 Apr 5:307:118668.

RNF4 PROTAC RD12

生物&药学活性

物理化学性质&存储条件

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RNF4 PROTAC RD12

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