RNF4 PROTAC RD12 | RNF4 degrader | Probechem Biochemicals

Chemical Structure : RNF4 PROTAC RD12

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RNF4 PROTAC RD12 (RNF4 degrader)

货号: PC-26975Not For Human Use, Lab Use Only.

RNF4 PROTAC degrader RD12 is an effective, selective RNF4 PROTAC degrader with DC50 of 4.16 uM in Huh7 cell line, degrades RNF4 via the ubiquitin-proteasome system and induces DNA damage and apoptosis.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

RNF4 PROTAC degrader RD12 is an effective, selective RNF4 PROTAC degrader with DC50 of 4.16 uM in Huh7 cell line, degrades RNF4 via the ubiquitin-proteasome system and induces DNA damage and apoptosis.
RD12 is capable of inducing RNF4 protein degradation in multiple HCC cell lines (HepG2, HCCLM6, Huh7).
RD12 displays profound antiproliferative activity both in vitro and in vivo.
RD12 elicits a significant anti-tumor effect in a HCC mouse model.

物理化学性质&存储条件

分子量	866.47
分子式	C47H52ClN5O7S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S,4R)-1-((S)-2-(4-(4-(4-(N-benzyl-2-chloroacetamido)phenoxy)phenoxy)butanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

参考文献

1. Hui Wan, et al. Eur J Med Chem. 2026 Apr 5:307:118668.