RET PROTAC RD-23

Chemical Structure : RET PROTAC RD-23

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货号: PC-23771Not For Human Use, Lab Use Only.

RET PROTAC RD-23 is a potent, selective and orally bioavailable RET PROTAC degrader with DC50 of 5.6 nM, Dmax =92% in BaF3 cells.

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RET PROTAC RD-23 is a potent, selective and orally bioavailable RET PROTAC degrader with DC50 of 5.6 nM, Dmax =92% in BaF3 cells.

分子量	927.08
分子式	C52H54N12O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-(4-(4-(5-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)pent-4-yn-1-yl)piperazin-1-yl)piperidin-1-yl)-4-(6-(6-((6-methoxypyridin-3-yl)methyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile

1. Hualong M, et al. J Med Chem. 2025 Jan 7. doi: 10.1021/acs.jmedchem.4c01889.