RBC8 | GTPase Ral inhibitor | Probechem Biochemicals

Chemical Structure : RBC8

CAS No.: 361185-42-4

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RBC8 (Ral inhibitor RBC8)

货号: PC-43276Not For Human Use, Lab Use Only.

RBC8 is a specific small molecule inhibitor of GTPase Ral, inhibits both RalA and RalB activation and colony formation of Ral-dependent lines H2122 and H358 in soft agar with IC50 of 3.5 and 3.4 uM, respectively.

规格	价格	库存
5 mg	￥980	In stock
10 mg	￥1480	In stock
25 mg	￥2580	In stock
50 mg	￥3980	In stock
100 mg		Get quote

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生物&药学活性

RBC8 is a specific small molecule inhibitor of GTPase Ral, inhibits both RalA and RalB activation and colony formation of Ral-dependent lines H2122 and H358 in soft agar with IC50 of 3.5 and 3.4 uM, respectively.
RBC8 acts specifically through the GDP-bound form of Ral proteins, RalAG23V or RalBG23V, mitigates inhibition of H2122 and H358 cell growth.
RBC8 shows selectivity for Ral relative to Ras or Rho and inhibits xenograft tumor growth similar to depletion of Ral by siRNA.
RBC8 also enhances the inhibitory effects of imatinib in K562, KCL22 and BaF3-P210 cells.

物理化学性质&存储条件

分子量	424.4513
分子式	C25H20N4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 40 mg/mL
Chemical Name/SMILES	Pyrano[2,3-c]pyrazole-5-carbonitrile, 6-amino-4-(2,5-dimethoxyphenyl)-1,4-dihydro-3-(2-naphthalenyl)-

参考文献

1. Yan C, et al. Nature. 2014 Nov 20;515(7527):443-7.

2. Gu C, et al. Oncotarget. 2016 Apr 12;7(15):20561-73.

3. Kodama T, et al. Gastroenterology. 2016 Aug;151(2):324-337.e12.

RBC8 (Ral inhibitor RBC8)

生物&药学活性

物理化学性质&存储条件

参考文献

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RBC8 (Ral inhibitor RBC8)

生物&药学活性

物理化学性质&存储条件

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