RAD51 PROTAC G73

Chemical Structure : RAD51 PROTAC G73

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货号: PC-27164Not For Human Use, Lab Use Only.

RAD51 PROTAC G73 is an effective RAD51 PROTAC degrader with DC50 of 268 nM in PC-3 cells.

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生物&药学活性

RAD51 PROTAC G73 is an effective RAD51 PROTAC degrader with DC50 of 268 nM in PC-3 cells.
G73 promotes RAD51 degradation by recruiting E3 ligase VHL to RAD51, enabling subsequent ubiquitination, induces degradation in a time- and VHL-dependent manner.
G73 enhances DNA damage and exhibits synergistic effects with the PARP inhibitor olaparib.
G73 potentiates PARP inhibitors to suppress tumor growth in xenograft mouse models.

物理化学性质&存储条件

分子量	1158.74
分子式	C57H69ClFN9O12S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-((2S,4R)-2-(((S)-1-(2-chloro-4-methoxyphenyl)ethyl)carbamoyl)-4-(((S)-14-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidine-1-carbonyl)-15,15-dimethyl-2,12-dioxo-6,9-dioxa-3,13-diazahexadecyl)oxy)pyrrolidin-1-yl)-2-oxoethyl)-6-fluoroquinoline-2-carboxamide

参考文献

1. Yanlin Jian, et al. Acta Pharm Sin B. 2026 Jun;16(6):3907-3919.

RAD51 PROTAC G73

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物理化学性质&存储条件

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RAD51 PROTAC G73

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