R4VPL3-1 | RNF4 degrader | Probechem Biochemicals

Chemical Structure : R4VPL3-1

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R4VPL3-1 (R4VP L3-1)

货号: PC-26976Not For Human Use, Lab Use Only.

R4VPL3-1 is a PROTAC-like molecule that induces proteasomal degradation of RNF4, also induces the elimination of VHL in cancer cells.

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生物&药学活性

R4VPL3-1 is a PROTAC-like molecule that induces proteasomal degradation of RNF4, also induces the elimination of VHL in cancer cells.
R4VPL3-1 has significant anti-cancer activity towards human squamous cancer cells (SCC1), inhibiting proliferation and sphere formation (SFA) with IC50 of 0.3 uM.
R4VPL3-1 induces death of human skin and melanoma cancer cells, but does not affect MEFs and non-oncogenic cells.
R4VPL3-1 induces ferroptosis in A375R RTKi-resistant melanoma cells, co-inactivates anti-ferroptotic selanoproteins such as GPX4, along with the elimination of RNF4 and the anti-ferroptotic E3 ligase VHL.

物理化学性质&存储条件

分子量	1082.75
分子式	C57H72ClN7O10S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2R,4R)-1-((R)-2-(tert-butyl)-18-(4-(4-(2-chloro-N-(4-(dimethylamino)benzyl)acetamido)phenoxy)phenoxy)-4,13-dioxo-7,10-dioxa-3,14-diazaoctadecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

参考文献

1. Oknin-Vaisman A, et al. Oncogene. 2026 Jun 5. doi: 10.1038/s41388-026-03829-2.

2. Carl C Ward, et al. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440.

R4VPL3-1 (R4VP L3-1)

生物&药学活性

物理化学性质&存储条件

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R4VPL3-1 (R4VP L3-1)

生物&药学活性

物理化学性质&存储条件

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