R1-ICR-5 | RIPK1 PROTAC | Probechem Biochemicals

Chemical Structure : R1-ICR-5

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R1-ICR-5 (RIPK1 PROTAC degrader)

货号: PC-22429Not For Human Use, Lab Use Only.

R1-ICR-5 is a selective and potent RIPK1 PROTAC degrader, triggers VHL-mediated degradation of RIPK1, deregulates TNFR1 and TLR3 signaling, enhances innate immune signaling and necroptosis

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R1-ICR-5 is a selective and potent RIPK1 PROTAC degrader, triggers VHL-mediated degradation of RIPK1, deregulates TNFR1 and TLR3 signaling, enhances innate immune signaling and necroptosis

物理化学性质&存储条件

分子量	1007.32
分子式	C54H70N8O7S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	cyclohexyl (5-(2-(12-(((R)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylisothiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-12-oxododecanamido)benzo[d]thiazol-6-yl)-2-methylpyridin-3-yl)carbamate

参考文献

1. Mannion J, et al. Immunity. 2024 May 15:S1074-7613(24)00230-9.

R1-ICR-5 (RIPK1 PROTAC degrader)

生物&药学活性

物理化学性质&存储条件

参考文献

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R1-ICR-5 (RIPK1 PROTAC degrader)

生物&药学活性

物理化学性质&存储条件

参考文献

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