Quinalizarin |CAS:81-61-8 Probechem Biochemicals

Chemical Structure : Quinalizarin

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Quinalizarin

货号: PC-62192Not For Human Use, Lab Use Only.

Quinalizarin is a potent, selective and cell-permeable inhibitor of CK2 with Ki of 58 nM.

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生物&药学活性

Quinalizarin is a potent, selective and cell-permeable inhibitor of CK2 with Ki of 58 nM.
Quinalizarin shows selectivity over DYRK1a, PIMs, HIPK2, MNK1, ERK8 and PKD1.
Quinalizarin inhibits endogenous CK2 and induces apoptosis more efficiently than Emodin in Jurkat cells.
Quinalizarin reduces cell viability with emphasis on adenocarcinoma cells harboring EGFR sensitive mutation, suppresses migration, and accelerates apoptosis in different human lung cancer cell lines.

物理化学性质&存储条件

分子量	272.212
分子式	C14H8O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1,2,5,8-Tetrahydroxyanthracene-9,10-dione

参考文献

1. Cozza G, et al. Biochem J. 2009 Jul 15;421(3):387-95.

2. Zhou Y, et al. Indian J Cancer. 2015 Dec;52 Suppl 2:e119-24.

3. Pan X, et al. Int J Oncol. 2016 Mar;48(3):1073-84.

Quinalizarin

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Quinalizarin

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