QC-01-175 | Tau PROTAC | Probechem Biochemicals

Chemical Structure : QC-01-175

CAS No.: 2267290-96-8

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QC-01-175 (Tau PROTAC)

货号: PC-73296Not For Human Use, Lab Use Only.

QC-01-175 is a hetero-bifunctional molecule designed to engage both tau and Cereblon (CRBN) to trigger tau ubiquitination and proteasomal degradation (tau PROTAC).

规格	价格	库存
2 mg	￥1880	In stock
5 mg	￥2980	In stock
10 mg	￥4580	In stock
25 mg		Get quote
100 mg		Get quote

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生物&药学活性

QC-01-175 is a hetero-bifunctional molecule designed to engage both tau and Cereblon (CRBN) to trigger tau ubiquitination and proteasomal degradation (tau PROTAC).
QC-01–175 effected clearance of tau in frontotemporal dementia (FTD) patient-derived neuronal cell models, with minimal effect on tau from neurons of healthy controls.
QC-01–175 also rescued stress vulnerability in FTD neurons, phenocopying CRISPR-mediated MAPT-knockout.

物理化学性质&存储条件

分子量	626.670
分子式	C33H34N6O7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethyl)-3-(5H-pyrido[4,3-b]indol-7-yl)propanamide

参考文献

1. M Catarina Silva, et al. Elife. 2019 Mar 25;8:e45457.

QC-01-175 (Tau PROTAC)

生物&药学活性

物理化学性质&存储条件

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QC-01-175 (Tau PROTAC)

生物&药学活性

物理化学性质&存储条件

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