QA-68-ZU81 (QA-68) | BRD9 PROTAC | Probechem Biochemicals

Chemical Structure : QA-68-ZU81

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QA-68-ZU81 (BRD9 degrader QA-68)

货号: PC-49151Not For Human Use, Lab Use Only.

QA-68-ZU81 (QA-68) is a EA-89-based BRD9 degrader that incorporates the EA-89 warhead into a cereblon (CRBN)-targeting proteolysis-targeting chimera (PROTAC).

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生物&药学活性

QA-68-ZU81 (QA-68) is a EA-89-based BRD9 degrader that incorporates the EA-89 warhead into a cereblon (CRBN)-targeting proteolysis-targeting chimera (PROTAC).
QA-68 causes concentration-dependent inhibition of proliferation of MV4-11, SKM-1 and Kasumi-1-luc+ cells (IC50=1-10 nM for MV4;11 and SKM-1, and IC50=10-100 nM for Kasumi-1-luc +), shows less sensitivity HEL, KO52 and THP-1.
QA-68 more effectively inhibits SKM-1 cell cycle progression than EA-89, affects cell growth, differentiation, and colony formation in AML cells.

物理化学性质&存储条件

分子量	1169.427
分子式	C61H72N10O10S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-7-(1-((1-(4-(4-(4-(4-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)but-3-yn-1-yl)piperazine-1-carbonyl)piperazin-1-yl)-4-oxobutanoyl)piperidin-4-yl)methyl)-3-methyl-1H-indol-5-yl)-4-oxo-5-propyl-4,5-dihydrothieno[3,2-c]pyridine-2-carboxamide

参考文献

1. Ellen Weisberg, et al. Blood Cancer J. 2022 Jul 19;12(7):110.

QA-68-ZU81 (BRD9 degrader QA-68)

生物&药学活性

物理化学性质&存储条件

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QA-68-ZU81 (BRD9 degrader QA-68)

生物&药学活性

物理化学性质&存储条件

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