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首页-小分子抑制剂&激动剂-Wnt/Notch/Hedgehog-Casein Kinase-Pyrvinium pamoate
Pyrvinium pamoate

Chemical Structure : Pyrvinium pamoate

CAS No.: 3546-41-6

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Pyrvinium pamoate (Pyrvinium embonate)

货号: PC-46115Not For Human Use, Lab Use Only.

Pyrvinium pamoate is an anthelmintic effective agent for pinworms that shows to be a potent inhibitor of Wnt signaling with EC50 of 10 nM, binds to all CK1 family members in vitro at low nanomolar concentrations and selectively potentiates CK1α kinase activity.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Pyrvinium pamoate is an anthelmintic effective agent for pinworms that shows to be a potent inhibitor of Wnt signaling with EC50 of 10 nM, binds to all CK1 family members in vitro at low nanomolar concentrations and selectively potentiates CK1α kinase activity.
Pyrvinium pamoate inhibits Wnt signaling downstream of β-catenin, and promotes Pygopus degradation.
Pyrvinium pamoate also is a potent inhibitor of HH signaling by reducing the stability of the Gli family of transcription factors.

物理化学性质&存储条件

分子量 575.70
分子式 C26H28N3 . 1/2 C23H14O6
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 24 mg/mL
Chemical Name/SMILES

Quinolinium, 6-(dimethylamino)-2-[2-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)ethenyl]-1-methyl-, 4,4'-methylenebis[3-hydroxy-2-naphthalenecarboxylate] (2:1)

参考文献

1. Thorne CA, et al. Nat Chem Biol. 2010 Nov;6(11):829-36.

2. Li B, et al. Cancer Res. 2014 Sep 1;74(17):4811-21.

3. Li B, et al. Sci Signal. 2017 Jun 27;10(485). pii: eaak9916.

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